Genomics in Action: Exploring the Viral World

Step into real research—one phage at a time

Step into the world of real scientific discovery through the study of bacteriophages—viruses that infect bacteria. In this hands-on, project-based course, you’ll learn how to design and carry out hypothesis-driven research while exploring the structure and genome of your own unique phage.

Working in a lab, you’ll isolate and characterize bacteriophages that infect mycobacterium, a harmless soil bacterium related to the one that causes tuberculosis. Along the way, you’ll practice essential lab skills such as sterile technique, solution preparation, DNA manipulation, and bioinformatic genome analysis.

Phage hunting combines art, science, and adventure—you’ll collect samples from the environment, investigate how phages interact with their bacterial hosts, and uncover the secrets hidden in their genetic code. By the end of the course, your discoveries will contribute to a growing scientific database that helps researchers better understand phage diversity, bacterial genetics, and even tuberculosis biology.

Program details

Course Code: PREC.601
Prerequisites/Skills Needed: Required: Biology, Preferred: Chemistry
Instructor: Michael Doody, Ph.D., Lecturer, UCSC Molecular, Cell, & Developmental Biology Department
Method: Commuter (Silicon Valley)
Dates: June 15 – 26, 2026
Times: 9:30 a.m. – 4:30 p.m., Monday through Friday
Cost: $2,500

Topics

  • Hunt and discover your own unique bacteriophage.
  • Learn real lab skills in DNA and genome analysis.
  • Explore how viruses interact with bacteria.
  • Contribute your discoveries to real scientific research.
  Topic Activity
Day 1 What are bacteriophages?
Learn how to work with and plate previously discovered bacteriophages
Day 2 Fundamentals of molecular biology DNA finger printing of previous bacteriophage; local bacteriophage enrichment of your soil sample
Day 3 What is a genome? Gel electrophoresis of DNA finger printing; online bioinformatic tools
Day 4 Bacteriophages’ contribution to molecular biology Plaque assay day 1
Day 5 Current research on Bacteriophages Plaque assay day 2: Picking a plaque, spot test
Day 6 How to build a biological ‘model’ Phage amplification
Day 7 Protein structure and function AlphaFold3 and ChimeraX
Day 8 Exploring Bacteriophage genomes Genomic tools, testable models
Day 9 Current research on bacteriophages Preserve your bacteriophages
Day 10 Review, wrap-up, how to pick a major Polish presentation materials
Final Team Presentations:  4:30 – 6 p.m.

Genomics in Action Instructor

Michael Doody, Ph.D.
Lecturer of Molecular, Cell and Developmental Biology, UCSC
B.S. and Ph.D., UC Santa Cruz

Michael Doody, Ph.D., is a proud UC Santa Cruz alumnus and dedicated educator passionate about hands-on STEM learning. His research experience spans DNA nanopore technology, chromatin structure and function, and genome-wide sequencing and bioinformatics. At UC Santa Cruz, Dr. Doody teaches a wide range of courses in molecular, cell, and developmental biology, from lab-based classes to upper-division lectures and research internships. He also co-leads the Molecular Biology Investigations Cluster for COSMOS. For Genomics in Action: Exploring the Viral World, Dr. Doody brings his enthusiasm for discovery and mentorship to guide high school students in uncovering the hidden diversity of bacteriophages across Silicon Valley.