Knowledge of how gene expression is regulated is essential to understanding cellular structure and function, both in normal cells and in the disease state. This course provides a solid foundation in the molecular concepts and cutting-edge technologies that are central to the study of gene expression pathways in simple cells (prokaryotes) and complex multicellular organisms.
- Basics of gene structure and gene regulatory elements- both cis and trans
- Transcriptional control of gene expression in prokaryotes and eukaryotes
- Post-transcriptional and translational control of gene activity
- Molecular techniques for studying gene expression
We will discuss abnormalities in gene expression pathways and how they relate to human diseases, including viral, immune and metabolic diseases, as well as cancer. We will also discuss the latest methods used to manipulate, monitor and analyze gene expression levels in cells and whole organisms, and the relevance of these techniques to research, drug discovery and diagnostic medicine.